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KMID : 0811820070110010016
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Journal of Korean Society of Pediatric Nephrology
2007 Volume.11 No. 1 p.16 ~ p.23
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Correlation between Serum Albumin Level and IgG Level in Minimal Change Nephrotic Syndrome
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Kwak Ga-Young
Lee Joon-Sung
Lee Kyung-Yil
Kim Dong-Un
Koh Dae-Kyun
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Abstract
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Purpose : Hypogammaglobulinemia has been observed in nephrotic syndrome, but its pathophysiology remains unknown. We evaluated the relationship between the serum IgG and at bumin levels for children with minimal change nephrotic syndrome(MCNS).
Methods : The levels of immunoglobulin G(IgG), albumin and total cholesterol of a total of 46 children with MCNS(proteinuria >40mgm^2h, and serum albumin level <2.5g/dL were analyzed.
Results : The mean values of albumin, IgG and total cholesterol in MCNS children were 1.7{±}0.3gdL,;368{±}143mgdL;and;431{±}78mgdL, respectively. There was an inverse correlation between the albumin values and the total cholesterol values(r=0.68, P=0.0001), whereas there was a direct-proportional correlation between albumin values and the IgG values(r=0.4, P=0.01).
Conclusion : The IgG level is associated with albumin level, and it may reflect the severity of urinary protein loss in MCNS. Further studies are needed to evaluate this phenomenon.
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KEYWORD
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Nephrotic Syndrome, Albumin, Cholesterol, Immunoglobuin G
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